In this session, we will discuss some of the innovative instructional and support programs of the OUWB School of Medicine. Our curriculum utilizes an organ systems-based approach to instruction during the M1 and M2 years, employing weekly integrative team-based learning sessions to encourage small student groups to apply recently acquired knowledge to solve relevant clinical problems. Basic science content will be reinforced in the M3 and M4 years using weekly small group cased-based sessions highlighting clerkship-specific basic science concepts. The OUWB curriculum also features a four-year capstone project for all students, encouraging students to pursue independent activity in bench, clinical or translational research, as well as education-related or service-related activities. This capstone program allows students to pursue their passion in a mentored environment, while producing scholarly work of scientific or social importance. Recognizing that the path to becoming a physician is enhanced through guidance and mentoring, OUWB has also established the PRISM program (Promoting Reflection and Individual growth through Support and Mentoring), providing students with a multi-layered system of support that begins the first day of medical school and continues to graduation.